Product name : Aliskiren
Item : cc228
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 173334-57-1
Molecular Weight : 551.76
Formula : C₃₀H₅₃N₃O₆
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Aliskiren is a direct renin inhibitor with an IC50 of 0.72 nM against renin. Renin is the first enzyme in the renin-angiotensin-aldosterone system which plays a role in blood pressure control. Renin cleaves angiotensinogen to angiotensin I, which is in turn converted by (ACE) to angiotensin II. Angiotensin II has both direct and indirect effects on blood pressure. It directly causes arterial smooth muscle to contract, leading to vasoconstriction and increased blood pressure. [1][2]
Reference:
[1] Circulation 2005, 111, 1012-1018.
[2] Lancet 2006, 368, 1449-1456.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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