Apoptosis
MNK
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Product name : SB 203580
Item : cc-50
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2850
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 152121-47-6
Molecular Weight : 377.43
Formula : C₂₁H₁₆FN₃OS
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27. SB 203580 is a potent inhibitor of LPS-induced cytokine synthesis in the human monocyte cell line THP-1 (IC50 = 50-100 nM). SB 203580 inhibited the RK from heat-shocked HeLa cells and osmotically stressed PC12 cells or bacterially expressed CSBP-2 with an IC50 of 0.6 μM.[1][2]
Reference:
[1] J Biol. Chem. 1996, 271, 6586-6589.
[2] J Biol. Chem. 1997, 272, 12116-12121.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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