Favorite  |  Set Home
Products > Cell Cycle > Microtubules > Epothilone A
Product name : Epothilone A
Item : cc632
Price : 200mg, $1750;500mg, $2690; 1g $3590; 2g, $5190
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 152044-53-6
Molecular Weight : 493.66
Formula : C26H39NO6S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
Epothilone A is a Taxol-like microtubule-stabilizing agent with EC0.01 of 2 μM. Epothilone A binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. [1][2]
 
Reference:
[1] J Med. Chem. 1991, 34, 1176-1184.
[2] Org. Lett. 2011, 3, 2693-2696.
 
 
Chemical Information
Molecular Weight (WM):
493.66
Formula:
C26H39NO6S
CAS No:
152044-53-6, 1285540-20-6 (2H2O)
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 99 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 99 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
ABT 751 (E7010)
ABT 751 (E7010)
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
Epothilone D
Epothilone D
Price: 100mg, $2150;200mg, $3290;
Combretastatin A4
Combretastatin A4
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
CYT 997
CYT 997
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
Epothilone B (EPO 906)
Epothilone B (EPO 906)
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590