Product name : Epothilone A
Item : cc632
Price : 200mg, $1750;500mg, $2690; 1g $3590; 2g, $5190
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 152044-53-6
Molecular Weight : 493.66
Formula : C26H39NO6S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Epothilone A is a Taxol-like microtubule-stabilizing agent with EC0.01 of 2 μM. Epothilone A binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. [1][2]
Reference:
[1] J Med. Chem. 1991, 34, 1176-1184.
[2] Org. Lett. 2011, 3, 2693-2696.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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