Apoptosis
Aurora Kinase
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Product name : Epothilone B (EPO 906)
Item : cc633
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 152044-54-7
Molecular Weight : 507.68
Formula : C₂₇H₄₁NO₆S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Epothilone B (EPO906) is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Epothilone B may cause complete cell-cycle arrest. [1][2]
Reference:
[1] J Med. Chem. 1991, 34, 1176-1184.
[2] Cancer Res. 1995, 55, 2325-2333.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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