Product name : GSK 429286A
Item : cc634
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 864082-47-3
Molecular Weight : 432.37
Formula : C₂₁H₁₆F₄N₄O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively. GSK-429286A is a more selective ROCK2 inhibitor than the widely utilized ROCK inhibitor Y-27632 as assessed on kinase-specificity panel, and does not significantly inhibit LRRK2 even at doses as high as 30 μM (500-fold higher than IC50 of inhibition of ROCK2). [1][2]
Reference:
[1] J Med. Chem. 2007, 50, 6-9.
[2] Biochem. J 2009, 424, 47-60.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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