Product name : GNF 2
Item : cc 647
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 778270-11-4
Molecular Weight : 374.32
Formula : C₁₈H₁₃F₃N₄O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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GNF-2 is an allosteric inhibitor of Bcr-abl tyrosine kinase activity (IC50 = 267 nM) and inhibits proliferation and induces apoptosis in Bcr-abl-expressing cells. GNF2 binds to the c-abl myristoyl binding pocket and acts as an allosteric, non-ATP-competitive inhibitor of cellular Bcr-abl activity and Bcr-abl-dependent cellular functions. [1][2]
Reference:
[1] Nat. Chem. Biol. 2006, 2, 95-102.
[2] J. Biol. Chem. 2009, 284, 29005-29014.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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