Apoptosis
Aurora
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Product name : SB 743921
Item : cc-399
Price : 200mg, $750;500mg, $1350; 1g $1950; 2g, $3150
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 940929-33-9
Molecular Weight : 553.52
Formula : C₃₁H₃₄Cl₂N₂O₃
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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SB 743921 is a second generation, highly potent and active KSP inhibitor with a Ki of 0.1 nM for KSP (Eg5). SB-743921 selectively inhibits kinesin spindle protein (KSP), an important protein involved in the early stages of mitosis that is expressed in proliferating cells. Inhibition of KSP results in inhibition of mitotic spindle assembly and interrupts cell division, thereby causing cell cycle arrest and induction of apoptosis. [1]
Reference:
[1] Caner Chemother. Pharmacol. 2011, 67, 447-454.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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