Apoptosis
Sigma Receptor
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Product name : Purmorphamine
Item : cc 676
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 483367-10-8
Molecular Weight : 520.62
Formula : C₃₁H₃₂N₆O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Purmorphamine directly binds and activates Smoothened with IC50 of ~ 1.5 μM in compete with Smo antagonist and also is a inducer of osteoblast differentiation with EC50 of 1μM. Purmorphamine has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. [1][2]
Reference:
[1] Chem. Biol. 2004, 11, 1229-1238.
[2] Nat. Chem. Biol. 2006, 2, 29-30.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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