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Products > Cell Cycle > Wee > MK 1775
Product name : MK 1775
Item : cc 686
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 955365-80-7
Molecular Weight : 500.6
Formula : C₂₇H₃₂N₈O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
MK-1775 is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM. MK1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2011, 10, 2405-2414.
[2] Mol. Cancer Ther. 2009, 8, 2992-3000.
 
 
Chemical Information
Molecular Weight (WM):
500.60
Formula:
C27H32N8O2
CAS No:
955365-80-7, 1075739-30-8 (H2O), 1075739-32-0 (XHCl)
Purity:
≥ 98%
Synonyms:
MK 1775
 
DMSO ≥ 80 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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