Apoptosis
KSp
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Product name : MLN 8237 (Alisertib)
Item : cc-313
Price : 200mg, $1350;500mg, $1950; 1g $2650; 2g, $3750
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1028486-01-2
Molecular Weight : 518.92
Formula : C₂₇H₂₀ClFN₄O₄
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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MLN 8237 is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with median IC50 of 61 nM. Alisertib binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers. [1][2]
Reference:
[1] Blood, 2010, 115, 5202-5213.
[2] Chem. Biol. 2010, 5, 563-576.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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