Product name : Dabrafenib (GSK 2118436)
Item : cc755
Price : 200mg, $459;500mg, $850; 1g, $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com
CAS : 1195765-45-7
Molecular Weight : 519.56
Formula : C₂₃H₂₀F₃N₅O₂S₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Dabrafenib (GSK-2118436) is a potent ATP-competitive inhibitor of B-Raf, B-RafV600E and c-Raf with IC50 of 3.2 nM, 0.8 nM and 5.0 nM, respectively. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. [1][2]
Reference:
[1] Mol. Cancer Ther. 2012, 11, 909-920.
[2] JAMA Dermatol. 2013, 149, 322-326. .
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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