Product name : Raltitrexed (Tomudex)
Item : cc 761
Price : 200mg, $459;500mg, $850; 1g, $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
CAS : 112887-68-0
Molecular Weight : 458.49
Formula : C₂₁H₂₂N₄O₆S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Raltitrexed (Tomudex) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate activity and DNA replication and repair and resulting in cytotoxicity. [1]
Reference:
[1] Eur. J Cancer 1995, 31A, 1277.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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