Product name : RN 486
Item : cc788
Price : 200mg, $1250;500mg, $2090; 1g, $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
CAS : 1242156-23-5
Molecular Weight : 606.69
Formula : C₃₅H₃₅FN₆O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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RN-486 is a Bruton's tyrosine kinase (Btk) inhibitor. RN486 not only potently and selectively inhibited the Btk enzyme, but also displayed functional activities in human cell-based assays in multiple cell types, blocking Fcε receptor cross-linking-induced degranulation in mast cells (IC(50) = 2.9 nM), Fcγ receptor engagement-mediated tumor necrosis factor α production in monocytes (IC(50) = 7.0 nM), and B cell antigen receptor-induced expression of an activation marker, CD69, in B cells in whole blood (IC(50) = 21.0 nM). [1][2]
Reference:
[1] Immunol. Lett. 2013, 150, 97-104.
[2] J Pharmacol. Exp. Ther. 2012, 341, 90-103.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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