Apoptosis
Sigma Receptor
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Product name : SB 277011
Item : cc-478
Price : 200mg, $1250;500mg, $2150; 1g $3050; 2g, $4250
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
CAS : 215803-78-4
Molecular Weight : 438.56
Formula : C₂₈H₃₀N₄O
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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SB-277011 is a drug which acts as a potent and selective dopamine D3 receptor antagonist, which is around 80-100x selective for D3 over D2, and lacks any partial agonist activity.
SB-277011 is used in the study of addiction to stimulant drugs such as nicotine and cocaine. Where cocaine reduces the threshold for brain electrical self-stimulation in rats, an indication of cocaine's rewarding effects, SB-277011 completely reverses this effect. It may thus be useful in the treatment of addiction to nicotine and cocaine, and is also being investigated for potential uses in the treatment of other drug addictions, such as addiction to heroin and alcohol.[1][2]
Reference:
[1] J Med. Chem. 2000, 43, 1878-1885.
[2] Brain Research 2007, 1149, 50-57.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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