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Products > GPCR > CCR2 > INCB8761(PF-4136309)
Product name : INCB8761(PF-4136309)
Item : CR1861
Price : 200mg, $950;500mg, $1695; 1g, $2490; 2g, $3590
contact : Send inquiry to: info@acesobio.com
CAS : 1341224-83-6
Molecular Weight : 568.59
Formula : C₂₉H₃₁F₃N₆O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
 Chemical Information
M.Wt 568.59 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C29H31F3N6O3
CAS No 1341224-83-6
Solubility

DMSO

Biological Activity of INCB8761(PF-4136309)

 

INCB8761(PF-4136309) is a Potent, Selective, and Orally Bioavailable CCR2 Antagonist.

 

1 . Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist By Xue, Chu-Biao; Wang, Anlai; Han, Qi; Zhang, Yingxin; Cao, Ganfeng; Feng, Hao; Huang, Taisheng; Zheng, Changsheng; Xia, Michael; Zhang, Ke; et ACS Med. Chem. Lett., 2011, 2 (12), pp 913-918
Abstract
We report the discovery of a new (S)-3-aminopyrrolidine series of CCR2 antagonists. Structure-activity relationship studies on this new series led to the identification of 17 (INCB8761/PF-4136309) that exhibited potent CCR2 antagonistic activity, high selectivity, weak hERG activity, and an excellent in vitro and in vivo ADMET profile. INCB8761/PF-4136309 has entered human clinical trials."

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