CAS#1431698-10-0

Chemical Formula: C25H29Cl3N4O2
Exact Mass: 522.13561
Molecular Weight: 523.88

OTSSP167 free base
Chemical Formula: C25H28Cl2N4O2
Exact Mass: 486.15893; Molecular Weight: 487.42
Elemental Analysis: C, 61.60; H, 5.79; Cl, 14.55; N, 11.49; O, 6.56

Description of OTSSP167:   OTSSP167 is a MELK selective inhibitor, exhibits a strong in vitro activity, conferring an IC50 of 0.41nM and in vivo effect on various human cancer xenograft models. Murine protein serine/threonine kinase 38 (MPK38), also known as maternal embryonic leucine zipper kinase (MELK), has been associated with various human cancers and plays an important role in the formation of cancer stem cells. MELK was also reported to be highly upregulated in multiple types of human cancer. It was implied to play indispensable roles in cancer cell survival and indicated its involvement in the maintenance of tumor-initiating cells.