Apoptosis
VDAC
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Product name : Vernakalant (RSD 1235)
Item : cc-484
Price : 200mg, $750;500mg, $1250; 1g $1950; 2g, $3050
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 794466-70-9
Molecular Weight : 349.46
Formula : C₂₀H₃₁NO₄
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Vernakalant (RSD 1235) blocks atrial potassium channels, thereby prolonging repolarization. It differs from typical class III agents by blocking a certain type of potassium channel, the cardiac transient outward potassium current, with increased potency as the heart rate increases. This means that it is more effective at high heart rates, while other class III agents tend to lose effectiveness under these circumstances. It also slightly blocks the hERG potassium channel, leading to a prolonged QT interval. This may theoretically increase the risk of ventricular tachycardia, though this does not seem to be clinically relevant.[1][2]
Reference:
[1] Nature Rev. Drug Disc. 2010, 9, 915-916.
[2] J Cardiovas. Electrophysiol. 2005, 16, 1227-1238.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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