Apoptosis
TAM Receptor
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Product name : FGF-401 (Synonyms: roblitinib)
Item : C2458
Price : 200mg, $1250;500mg, $2090; 1g, $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com
CAS : 1708971-55-4
Molecular Weight : 506.56
Formula : C25H30N8O4
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
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| Details: |
Description of:FGF-401 (Synonyms: roblitinib)
FGF-401(CAS:1708971-55-4),also known as roblitinib, is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, FGF401 binds to and inhibits the activity of FGFR4, which leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. FGFR4 is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cell proliferation, differentiation, angiogenesis, and survival. FGF-401 is a FGFR4 inhibitor developed for the treatment of solid tumor. FGF-401 is a FGFR4 inhibitor in phase I/II clinical studies for the treatment of positive FGFR4 and KLB expresion solid tumors and hepatocellular carcinoma. Quality control data: Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS. Product will be shipped with supporting analytical data. REFERENCES[1]. WO2015059668A1 |
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