Apoptosis
MAO
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Product name : Go 6976
Item : cc 694
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 136194-77-9
Molecular Weight : 378.43
Formula : C24H18N4O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Go-6976 is a potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Go6976 discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro and selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Go 6976 does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Go 6976 also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint. [1][2]
Reference:
[1] Neuroscience 2002, 114, 689-697.
[2] Cancer Res. 2004, 64, 5693-5701.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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