TCS JNK5a

TCS JNK5a is a selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α respectively)....

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VX 702

VX-702 is an orally bioavailable inhibitor of p38 MAP kinase that inhibits platelet agonist induced p38 activation (IC50= 4 to 20 nM). Pre-incubation ...

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NVP-BHG712

NVP-BHG712 is a small molecule specific EphB4, VEGFR2, c-raf, c-src and c-Abl kinase inhibitor with ED50 of 25 nM, 4.2, 0.4, 1.3 and 1.7μM, respect...

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LY 2228820

LY2228820 is aa novel and potent p38MAPK inhibitor (IC50 for p38αMAPK and p38βMAPK were 7 nM and 3 nM, respectively). LY2228820 enhances ...

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SB 203580

SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27. SB ...

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Vinorelbine (Navelbine)

Vinorelbine was invented by the pharmacist Pierre Potier and his team from the CNRS in France in the 1980s. It is the first 5´NOR semi-synthetic...

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TAK 715

TAK-715 is a inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα). TAK-715 also inhibits Wnt-3a-stimulated β-catenin signaling. Inhibits 22 ...

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SB 202190

SB 202190 is al highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (Kd = 38 nM,...

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VX 745

VX-745 is highly potent and selective p38α inhibitor (IC50 = 10 nM). VX-745 also blocks TNFα production in LPS-stimulated HWB in vitro (IC...

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Doramapimod (BIRB 796)

The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such ...

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SB 239063

SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK...

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AS 602801 (Bentamapimod)

AS 602801 is a novel, orally active, Jun Kinase Inhibitor. ...

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CC 401

CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Based o...

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GW 5074

GW 5074 is a potent, cell-permeable, reversible, and ATP-competitive cRAF1 kinase inhibitor (IC50 = 9 nM). It shows ≥100-fold selectivity for Raf k...

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AZ 628

AZ628 is a potent tyrosine protein inhibitor for wild-type CRAF and BRAF V600E with IC50 of 29 and 34 nM, respectively. AZ628 inhibits activities of p...

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Sorafenib (Nexavar)

Sorafenib is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 o...

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